Simplified Global Nonlinear Function for Fitness Landscape of Protein Design

On Simplified Global Nonlinear Function for Fitness Landscape: A Case Study of Inverse Protein Folding

The construction of fitness landscape has broad implication in understanding molecular evolution, cellular epigenetic state, and protein structures. We studied the problem of constructing fitness landscape of inverse protein folding or protein design, with the aim to generate amino acid sequences that would fold into an a priori determined structural fold which would enable engineering novel or...

Nonlinear Fitness Landscape of a Molecular Pathway

Genes are regulated because their expression involves a fitness cost to the organism. The production of proteins by transcription and translation is a well-known cost factor, but the enzymatic activity of the proteins produced can also reduce fitness, depending on the internal state and the environment of the cell. Here, we map the fitness costs of a key metabolic network, the lactose utilizati...

global results on some nonlinear partial differential equations for direct and inverse problems

در این رساله به بررسی رفتار جواب های رده ای از معادلات دیفرانسیل با مشتقات جزیی در دامنه های کراندار می پردازیم . این معادلات به فرم نیم-خطی و غیر خطی برای مسایل مستقیم و معکوس مورد مطالعه قرار می گیرند . به ویژه، تاثیر شرایط مختلف فیزیکی را در مساله، نظیر وجود موانع و منابع، پراکندگی و چسبندگی در معادلات موج و گرما بررسی می کنیم و به دنبال شرایطی می گردیم که متضمن وجود سراسری یا عدم وجود سراسر...

Fitness landscape analysis and design of metaheuristics for car sequencing

We study the car sequencing (CS) problem, an NPhard combinatorial optimization problem which aims at finding a production sequence of different models launched down a mixedmodel assembly line. The models are differentiated by a number of selected options. For each option, a so-called sequencing rule is applied which restricts the option occurrences in the sequence in order to minimize the work ...

Nonlinear Fitness Landscape of a Molecular Pathway Supplementary Material